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Abd Eldaim MA, Ibrahim FM, Orabi SH, Hassan A, El Sabagh HS (2018) l-Carnitine-induced amelioration of HFD-induced hepatic dysfunction is accompanied by a reduction in hepatic TNF- and TGF-1
A 2024 paper in Science used optogenetics and human fMRI to identify GLP-1 receptor neurons in the dorsomedial hypothalamus as the substrate for the preingestive satiation these drugs produce the sense of fullness before you finish eating
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Factors that may influence perioperative management include: Medication characteristics : Daily GLP-1 medications (liraglutide, oral semaglutide) have shorter durations of action than weekly formulations (injectable semaglutide, dulaglutide, exenatide extended-release) [3] Risk factors : Higher doses, recent dose increases, active gastrointestinal symptoms, or known gastroparesis may increase risk [1] [3] Procedure type : More complex surgeries or those requiring general anaesthesia may warrant different approaches than minor procedures Individual patient factors : BMI, presence of diabetes, and other medical conditions Some anaesthetists may recommend temporarily pausing GLP-1 therapy before certain procedures, particularly for patients with additional risk factors
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