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It's worth noting that GLP-1 receptor agonists should not be used in combination with DPP-4 inhibitors, as both work on the same pathway and NICE does not recommend this combination

Both semaglutide and tirzepatide are administered as a once-weekly subcutaneous injection that you conduct yourself at home

One way GLP-1 medications control appetite is by slowing digestion, allowing food to stay in the stomach and digestive tract longer, says Gupta

There is limited published clinical evidence specifically examining the safety and efficacy of combining topiramate and semaglutide

This increases intragastric pressure and can promote reflux of stomach contents into the oesophagus, leading to heartburn and reflux symptoms