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This modification dramatically reduces binding to IGF-binding proteins (IGFBPs), extending its half-life from ~15 minutes (native IGF-1) to 2030 hours

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Santoro B, Bigini P, Levandis G, Nobile V, Biggiogera M, Botti F, Mennini T, Curti D (2004) Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease

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