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Collectively, these structural and dynamic insights establish a foundation for understanding the mechanisms underlying catalytic Thi4 function and provide a rationale for how mutations, such as D168G, improve Thi4 function in model organisms grown in aerobic conditions

10.1074/jbc.m111.229518 J

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Glutathione is integral to this system, influencing various immune functions: Enhancing Immune Function T-Cell Activation : Glutathione supports the proliferation and activation of T-cells, which are essential for adaptive immunity