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Glucagon-like peptide type 1 receptor agonistsIncretin effect and systemic effects of glucagon-like peptide type 1 and its agonists The incretin effect describes the phenomenon whereby oral glucose elicits higher (23 times) insulin secretory responses than does intravenous glucose.25 This is due to incretin hormones, such as GLP-1 or glucose-dependent insulinotropic polypeptide, which stimulate insulin secretion in response to food intake

For example, studies on rodents have long established that feeding them a diet rich in both easily digestible fats and sugars will make them obese

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