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In high fat diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice model and HK-2 cells, after treatment with metformin (200 mg/kg/d) for 24 weeks, some indicators of mitophagy (LC3II, Pink1, Parkin, Atg5) were examined

There are however, many patients who do not suffer from any of the above historical side effects but rather have dermatologic mild responses like slight swelling or redness around the injection site

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However, despite a growing interest in mapping the post-translational 20 , metabolic 21 and lipidomic 22,23 landscapes of AML, a unified multiomic classification that can be clinically exploited is currently lacking

This biochemical process is also involved in the protection against environmental toxicants, carcinogens, dietary toxins and participates in the homeostasis of numerous endogenous molecules, including bilirubin, steroid hormones and biliary acids