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The company plans to submit its data for approval to the FDA and other regulators by mid-year

it is a completely different mechanism," Kroon said

Structures of the glucagon receptor (GCGR), the closest homolog of GLP-1R, have revealed key differences between the peptide-free and peptide-bound states, including an interesting -sheet motif in the peptide-free structure comprised of the stalk region and extracellular loop 1 ( ECL1) 9,14

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Additionally, Phenylbutazone has excellent bioavailability (up to 90%) 111, 113 and long half-life (50-105 hrs) 111 , which may enable dose de-escalation, further decreasing risks