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For instance, in 3xTg-AD mice, sex-specific alterations in brain bioenergetics have been observed: females showed impaired complex I activity in synaptic cortical mitochondria, while non-synaptic mitochondria exhibited enhanced complex IImediated respiration (Stojakovic et al., 2021)
Brill AL, Wisinski JA, Cadena MT, Thompson MF, Fenske RJ, Brar HK, et al
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& Giugliano, D
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