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Mounjaro (tirzepatide) works on both GLP-1 and GIP receptors and has shown greater average weight loss in trials (around 21% on the highest dose over 72 weeks compared with 15% for Wegovy 2.4 mg, or 21% on the new Wegovy 7.2 mg dose)
Kaufman and Ruhoy and their free Unraveled series
Two structural features distinguish it: amino-acid substitutions that resist degradation by the DPP-4 enzyme, and a fatty-acid chain that promotes albumin binding
Talley, Nicholas
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