That 6.25-fold difference in milligrams doesn't mean Zepbound is "weaker." It means the molecules have different receptor binding affinities, different half-lives (both around 5 days, but with different distribution kinetics), and different dose-response curves
I started microdosing tirzepatide not with the goal of weight loss, but to experience a shift in how I approached life
Potts JE, Gray LJ, Brady EM, Khunti K, Davies MJ, Bodicoat DH
We order vitamin B12 and folate testing when a person with Down syndrome we are evaluating has symptoms described above, has a lab abnormality for which follow up testing of vitamin B12 and/or folate is indicated, or the person has a condition in which deficiency is common (e.g., celiac disease)
This is because better blood sugar control and weight loss can lead to fewer symptoms of type 2 diabetes, such as fatigue and frequent urination