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According to NICE guidance (NG129) and the British Society of Gastroenterology guidelines, first-line therapy often includes corticosteroids (e.g., prednisolone or budesonide) for acute flares, followed by immunosuppressants such as azathioprine or methotrexate for maintenance

Clinicians have gained experience managing patients who transition from other GLP-1 receptor agonists to tirzepatide, noting that prior tolerance of GLP-1 therapy generally predicts better tolerance of Mounjaro, though gastrointestinal effects may still occur

Others prefer starting directly with tirzepatide for its superior efficacy data

There's no wrong answer here

Understanding the specific nature and severity of those side effects is critical for making an informed decision