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25 Safety and Tolerability As observed in previous studies, GI AEs were the most common side effects in both groups, with a higher incidence in the semaglutide arm

demonstrated that diseases involving coupled metabolic reactions co-occur three to seven times more frequently than those without such connections 11

Absorption is often most efficient when there is no competition from food

GI side effects (nausea, vomiting, diarrhoea) are dose-dependent

Given as a single agent, it promotes modest increases in survival, and these effects are enhanced when combined with oxaliplatin and/or irinotecan (FOLFOX, FOLFIRI) 2,3