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Depending on your treatment, you may have a legal obligation to notify the DVLA of your condition, and there are defined rules around blood glucose levels before and during driving
Depending on the patient and their prior surgery, this can include conversion to a duodenal switch (SADI-S or BPD/DS) or Roux-en-Y gastric bypass
The SUMMIT trial took this further with tirzepatide, showing a 38% reduction in the composite of cardiovascular death or worsening heart failure (HR 0.62) in patients with HFpEF and obesity, along with a clinically meaningful 6.9-point improvement in KCCQ scores
The volcano plots of DEGs are shown in Figure 1A and B, respectively
Collectively they belong to a class of glucagon-like peptide 1 (GLP-1) analogs that has reshaped the treatment of obesity and diabetes so thoroughly that the word blockbuster barely covers it
