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GLP-1 medications work on brain reward pathways and appetite centres, potentially reducing food cravings and loss-of-control eating beyond simple hunger suppression
And hepatic steatosis resolved in greater than 85% of participants with retatrutide 8 mg and 12 mg at week 48. The safety profile of retatrutide in the NAFLD subset was similar to that in the obesity population, and no hepatotoxicity signals in obesity or NAFLD was seen through week 48
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Salama et al
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