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Upon binding of GLP-1 receptor agonists, GLP-1R activates multiple intracellular cascades, including cAMP/PKA/CREB, MAPK/ERK, and PI3K/AKT

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Activated PKA promotes the PI3K/mTOR pathway in -cells, leading to the activation of the Hypoxia-Inducible Factor 1 (HIF-1)

Key Takeaways: People often urinate more as an indirect result, not from the drugs main effect