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In line with this, mice with an -cell specific knock-down of PC1/3, resulting in significantly reduced islet GLP-1 content, were able to maintain normal glucose tolerance, suggesting that islet GLP-1 may not be essential and/or that it can be compensated for by intestinally derived GLP-1 under normal conditions
However, many people find that the benefits are well worth the cost
Its main drawback is its unpleasant taste
In addition, this treatment is not intended for pregnant or breastfeeding women
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