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Consciously breathing out during needle entry and keeping the injection area relaxed allows the needle to pass through tissue more easily
These symptoms typically occur during dose escalation and often diminish with continued use, but they may be more pronounced in patients with altered gastrointestinal anatomy following surgery
The AGA and ACG provide evidence-based guidelines emphasizing treat-to-target strategies, with objective monitoring through endoscopy, cross-sectional imaging, and biomarkers (C-reactive protein, fecal calprotectin) to assess mucosal healing and optimize outcomes
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