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These techniques allowed us to, in an unbiased manner, see the difference between whats essential in metastasis and whats essential in the primary tumor, DelGaudio says

Rather than stimulating metabolism directly, it alters upstream behavioral drivers of energy consumption

HIFs are key transcriptional regulators mediating cellular adaptation to hypoxic environments [484], primarily regulating the expression of a series of oxygen-dependent genes [485]

MOTS-c also influences the folate cycle through AICAR accumulation [2], raising an unresolved question about interaction with methotrexate or other antifolate medications

McClean PL, Parthsarathy V, Faivre E, Hlscher C