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Wettergren A, Schjoldager B, Mortensen PE, Myhre J, Christiansen J, and Holst JJ

Equity concerns with trendy new drugs As the demand for GLP-1 drugs grows and some online companies make it easy for off-label use of the medications, some doctors are concerned about patients having equitable access to the meds

The 12mg dose is the highest tested in trials and produced the most weight loss (up to 28.7% of body weight)

Novo Nordisk's key formulation patent (US 9,714,283, filed 2013) covers the phosphate-buffered solution used in Ozempic and Wegovy, with specific pH ranges and phenol concentrations

GLP-1s are powerful medications, and many users experience side effects including nausea, constipation, stomach pain, and reflux that can result in a drastically reduced food intake and rapid weight loss