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Furthermore, a long heparan molecule could potentially bind to both of HGF I and II simultaneously, thus stabilizing the 2:2 c-MET/HGF complex
Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD
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[ref] Tissue remodeling and fibrosis are seen in animal models of hyperoxaluria
S., Ravi, S
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