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The complex is eventually released from lysosomes and transported across the cell membrane bound to one of two proteins in the blood circulation: Haptocorrin, which is responsible for the transport of B 12 to the liver

J., Dansen, T

The combined effect of LPS and IFN revealed the largest increase in endothelial permeability and there was a significant loss of the glycocalyx, accompanied by a further decrease in heparan sulfate proteoglycan 2

The concentration of produced ammonia was detected using an Ammonia Assay Kit (Abcam, Cambridge, UK) according to the manufacturers instructions