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A lack of carnitine in dialysis patients is caused by insufficient carnitine synthesis and by the loss through dialytic membranes, leading, in some patients, to carnitine depletion and a concomitant relative increase in esterified forms of carnitine [43]

Overall, these results demonstrate that both TZP and Sema can be effectively retained in PNP hydrogel depots with minimal passive diffusion, supporting the platforms utility for long-acting subcutaneous delivery

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On the flip side, if the plateau comes with solid lab results, better energy, and improved quality of life, maintaining your current weight might be the win