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The Impact of GLP-1 on the Balance between Bone Formation and Bone Resorption Normal bone metabolism in humans involves both bone formation and bone resorption in a balanced state of equilibrium

What the Phase 3 doses tell us The Phase 3 maintenance doses of 4mg, 9mg, and 12mg represent a refinement of the Phase 2 protocol

While its difficult to quantify many of these, the chart below identifies and describes many of these strategies

34 EphA4 knockout mice have dramatically reduced body size and impaired GHR signaling: they have normal levels of GH mRNA expression in the pituitary but have reduced plasma IGF1 and reduced IGF1 mRNA expression in the liver