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Research suggests the peptide may interact with fundamental cellular processes that govern how cells age and repair themselves over time

For the CagriSema combination, gastrointestinal adverse events affected 79.6% of participants compared to 39.9% with placebo

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The following sections examine representative systemsapelin, spexin, meteorin-like protein (METRNL), and oxyntomodulinwith explicit attention to the evidence supporting their metabolic roles, the reasons for historical underexploration, and the translational questions that remain unresolved