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amylin receptors in area postrema/NTS) and overlapping but distinct effects on gastric emptying and satiety signaling

Proposed Mechanism BPC-157 appears to work through multiple pathways: Maintaining vesicular integrity (affecting VMATs and dopamine transporters) Possibly occupying its own vesicular storage sites Competing for dopamine receptor binding Functionally substituting when dopaminergic neurons are lost This last property, essentially filling in for missing dopamine function, would explain why the peptide counteracts both receptor agonists (apomorphine) and antagonists (haloperidol, fluphenazine, clozapine, sulpiride) with equal effectiveness

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doi: 10.1016/j.jss.2023.05.006 51 LiJLuKSunFTanSZhangXShengWet al

When prescribed and monitored by your provider, BPC-157 is considered safe and well tolerated