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Stress and sleep can shift your brain signals, your hormones, and even immune activity in ways that affect sex
Combining with DPP-4 inhibitors is generally not recommended, as both drug classes work on the incretin system Adding basal insulin for those with more significant hyperglycaemia, which can be used alongside GLP-1 medications (with careful monitoring for hypoglycaemia) Switching to insulin therapy entirely may be necessary for those with advanced beta cell failure For weight management , when GLP-1 medications don't produce adequate weight loss, alternatives include: Orlistat , a lipase inhibitor that reduces fat absorption, though weight loss is typically modest (2-3 kg on average) Naltrexone-bupropion (Mysimba), which works on appetite centres through different pathways
Discuss benefits and risks with your provider before starting treatment
More recently, in December, the FDA approved semaglutide for weight loss in adolescents aged 12 to 17 years with an initial BMI in the 95th percentile for age and sex
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