However, according to data nausea, vomiting, diarrhea, and constipation affect 40%70% of patients on GLP-1 medications
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The REWIND cardiovascular outcome trial also revealed that dulaglutide administration resulted in inferior ocular outcomes, leading to an increased need for interventions such as photocoagulation, anti-vascular endothelial growth factor (VEGF) therapy, or vitrectomy compared to placebo recipients [38]
Nature 466 , 197202 (2010)
The appetite suppression you feel immediately after injection is just the peak effect, not the only time its active