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Glutathione is very sensitive to oxidation and processing
The 2-OH-E1 route catalyzed by CYP1A1 is a stable route, and it can be easily metabolized further through methylation, which is accomplished by catechol-O-methyltransferase (COMT)
Most of it splashes everywhere before getting through
Medications Some medicines including certain antibiotics, anti-seizure drugs, and chemotherapy agents can cause drug-induced pigmentation as a side effect
However, those with liver or kidney disease, pregnant women or patients undergoing intensive treatments should consult their physician first
