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a G protein-coupled receptor) agonist exendin-4 suppressed -aminobutyric acid receptor (GABAR)-mediated currents through GLP-1Rs in isolated rat retinal ganglion cells (GCs)

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Kanoski SE, Alhadeff AL, Fortin SM, Gilbert JR, Grill HJ (2014)

According to FDA prescribing information, the most frequently reported adverse reactions include: Gastrointestinal symptoms: Nausea (24-30% of patients) often most pronounced after dose increases Vomiting (8-12% of patients) typically occurs when nausea is severe or unmanaged Diarrhea (18-24% of patients) can range from mild to moderate in severity Constipation (16-17% of patients) paradoxically occurs alongside diarrhea in some individuals Abdominal pain or discomfort (10-14% of patients) often described as cramping or bloating Dyspepsia (6-9% of patients) indigestion, heartburn, or upper abdominal discomfort Gastroesophageal reflux disease (5-7% of patients) Eructation (belching) (5-7% of patients) These symptoms frequently overlap and compound one another

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