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Cost: Side Effects: Injection site reactions, water retention, and changes in insulin sensitivity

Diabetes Care 25:13981404 Fonseca V, Baron M, Shao Q, Dejager S (2008) Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitus

Efficacy and safety of degludec versus glargine in type 2 diabetes

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Metabolic effects : Both substances influence glucose metabolism and insulin sensitivity, though through different mechanisms