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This behavior is consistent with the lack of interaction of Trolox with AX and the complex interaction exhibited by TCEP with the antibiotic as revealed by 1 H-NMR ( Table 2 )

Maintenance sessions are needed

Dodd RD, Lee CL, Overton T, Huang W, Eward WC, Luo L, et al

Lower cagrilintide doses in combinations When combining, can reduce cagrilintide: 1.8mg cagrilintide + 2.4mg semaglutide: Still very effective (14-18% weight loss estimated) Better tolerated than both at 2.4mg Cost savings on cagrilintide Consider if GI-sensitive 1.2mg cagrilintide + 2.4mg semaglutide: Modest benefit from cagrilintide addition Minimal GI side effects from cagrilintide Semaglutide does heavy lifting May still achieve 12-15% total weight loss Testing approach: Start with standard doses (both 2.4mg) If intolerable, reduce cagrilintide first Maintain semaglutide at 2.4mg (well-tolerated, established) Find optimal cagrilintide dose for your tolerance Maintenance dosing after weight loss Strategies to sustain results long-term

Acknowledgements This research received no funds