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Important safety considerations: Tirzepatide may reduce the effectiveness of oral contraceptivesuse additional contraception for 4 weeks after starting treatment and after each dose increase There is a risk of gallbladder disease (cholelithiasis, cholecystitis) with weight loss Monitor for signs of pancreatitis (severe abdominal pain radiating to the back) Risk of hypoglycaemia increases when combined with insulin or sulphonylureas Significant gastrointestinal symptoms may lead to dehydration and affect kidney function In patients with type 2 diabetes and retinopathy, rapid improvement in glucose control may worsen retinopathy temporarily Not recommended during pregnancy or breastfeeding Should not be used in combination with other GLP-1 receptor agonists Patients should contact their GP if they experience persistent vomiting, severe abdominal pain, or signs of dehydration

Common side effects may include: Nausea Diarrhea or constipation Heartburn or indigestion Decreased appetite (which is also the intended effect) Fatigue For many, these symptoms are mild and fade as the body adjusts