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TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring intracellular protein associated with cytoskeletal dynamics

Cardiovasc Toxicol

(9(6)) doi:10.3390/brainsci9060137

Melatonin decreases ROS levels by neutralizing and increasing the antioxidant enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase) expression and activity (104, 109, 110)

Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism