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The ICD-10-CM Alphabetic Index provides multiple entry points for Crohns disease
[4] Respiratory symptoms are prominent, and patients often feel severely unwell with systemic features
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These are considered hypersensitivity reactions per product labeling
Additionally, various difficult toxicities associated with MTX such as testicular toxicity, which is regarded as a severe adverse effect that may result in infertility, may limit the drugs therapeutic impact (Howard et al
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