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However, the authors concluded that the higher dose of HFC combined with MSM was crucial for the improvement in skin hydration

These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46

The study compared three administration routes intraperitoneal, oral (in drinking water), and topical (thin cream layer) all delivered without a carrier

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