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Biomarker Verification To verify target engagement in humans without direct hippocampal transcriptomics, peripheral proxy markers must be monitored: For Intranasal GHK-Cu (Metabolic Dampening): Monitor systemic proxies for mTOR suppression and mitochondrial load

Results are mean SD of 3 independent experiments

doi: 10.1016/J.DIABRES.2022.110202 117 MacPhersonKCooperKHarbourJMahalDMillerCNairnM

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Scientists have also learned how to develop synthetic peptides (lab made versions), which have been designed to mimic or enhance these natural functions in the body