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studied the effect of ebselen treatment against the very high dose (20 Gy) -irradiation-induced toxicity in cultured cells and mice models (Table 2) [57]

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The evolution of GSH in aging fibroblasts showed a sudden increase in its concentration just before cell death, whereas GPx activity was already decreasing at the beginning of passages, and that of glutathione reductase was constant and reaching a very low level at the end of the cell culture, suggesting that the GSH system was probably involved in cell degeneration associated with aging [18]