This is one of the most common side effects of GLP-1 medications, along with nausea, vomiting, and stomach discomfort or abdominal pain
For long-term use, some providers reduce patients to a lower maintenance dose after reaching their weight goal
Obesity and Weight Management Research The primary focus of cagrilintide research has been its profound effects on body weight reduction [9] : Key Clinical Trial Data - Phase 2 ONWARDS 1 Design: 32-week, dose-ranging study in 706 adults with overweight/obesity Results (Cagrilintide monotherapy): [9] 0.3 mg weekly: -3.9% weight loss 0.6 mg weekly: -6.0% weight loss 1.2 mg weekly: -8.1% weight loss 2.4 mg weekly: -10.8% weight loss 4.5 mg weekly: -10.4% weight loss Mechanism: Weight loss attributed primarily to reduced energy intake (-535 kcal/day at 2.4 mg dose) rather than increased energy expenditure Research Implications: Cagrilintide provides a valuable research tool for investigating amylin receptor-mediated satiety pathways independent of GLP-1 signaling, offering insights into hormone-specific contributions to appetite regulation
Monitor for any adverse reactions
Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) binds at the AT 1 receptor subtype and mediates systemic blood pressure, body water/electrolyte balance and influences cerebral blood flow, cerebroprotection, seizure, stress and depression