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It is lipophilic and the acidic environment of the gastrointestinal tract can deactivate it, leading to its reduced bioavailability [144]
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In one melanoma study, mice exposed to higher NAC doses experienced greater metastatic activity than those given lower doses, suggesting the effect may be dose-dependent in certain experimental settings.42 Researchers have not established whether these findings apply to humans, but starting with a moderate dose offers a more conservative approach while still aligning with a large portion of the clinical literature
Mayo Clin Proc 88:544551
Additionally, since glutathione can influence cell health and metabolism, some patients might use these troches in the hopes of slowing down the aging process and contributing to overall wellness
