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REGULATION OF CELL DEATH BY mGSH As opposed to apoptosis, necrosis is a morphologically distinct form of cell death responsible for irreversible tissue destruction due to bioenergetic failure and oxidative damage
Accordingly, increased serum markers of intestinal barrier damage and epithelial apoptosis, such as intestinal fatty acid-binding protein (I-FABP), and cytokeratin 18 have been found in patients with T1D [59]
HGH therapy has been associated with fluid retention and oedema
According to NICE guidance (NG28), treatment intensification should be considered when HbA1c rises to 58 mmol/mol (7.5%) or higher on dual therapy
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