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Additionally, depression raises markers for epithelial barrier dysfunction, such as zonulin, leading to increased intestinal permeability and circulating lipopolysaccharide (LPS) levels

Deficiency of BMPR2, a core mediator of NK cell homeostasis, can lead to NK cell dysfunction by impairing IL-15 signaling, which is involved in the pathogenesis of PH (Figure 1, involves multi-dimensional mechanisms such as metabolic reprogramming, inflammasomes, complement pathways, and intercellular signal crosstalk, providing a rich theoretical basis for the development of immune-targeted therapeutic strategies for PH

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Amylin is attractive because it contributes to satiety and food intake regulation