Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired
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The breadth of documented activity reflects what the original investigators have described as systems-level pharmacology: rather than acting through a single high-affinity receptor, BPC-157 appears to modulate multiple intersecting cellular pathways including nitric oxide signalling, growth-factor receptor expression, dopamine and serotonin metabolism, and angiogenic vessel formation
The mechanism work mapping the VEGFR2 pathway was reported by the Chang research group at Chang Gung University, Taiwan, the only non-Zagreb laboratory to have published substantive original mechanism research on BPC-157 [2]
Management emphasizes consistent lid hygiene, warm compresses, and occasionally topical antibiotics