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The timing hypothesis now established in the literature suggests that initiating HRT before age 60 or within 10 years of menopause is associated with a substantially more favorable risk profile and, in some analyses, active cardiovascular benefit
Nevertheless, response patterns exhibit considerable individual variability, with weight loss ranging from 0% to over 10% among different patients
2024;11:e2308727
Approved and late-stage GLP-1 and incretin drugs (2026) Combination and multi-receptor mechanisms What distinguishes the modern pipeline is not just more of the same receptor but a widening menu of mechanisms
Sivalingam S, Larsen EL, van Raalte DH, Muskiet MHA, Smits MM, Tonneijck L, et al
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