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The background CV event rates from the placebo arms of previous RCTs with semaglutide were matched with the pre-adjudicated assumptions of the SOUL trial to create the predictive model
But it also means three sources of potential side effects, and a titration schedule that needs to account for all three receptor activations ramping up simultaneously
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Because the injection bypasses your digestive system, your body can access the B12 quickly instead of waiting for absorption from food
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