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doi: 10.1016/j.ceb.2025.102595 153 ArdenCParkSHYasasilkaXRLeeEYLeeMS

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Additionally, the metabolism of hypoxanthine plays an important role in regulating the production of H 2 O 2 and superoxide anions in IBS ( de novo synthesis of purines in intestinal epithelial cells is limited, requiring five ATP molecules for production of one purine molecule