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Observed molecular effects are dependent on experimental design, concentration, and model system, and are used to explore signalling mechanisms rather than defined biological or physiological outcomes
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PMID 28684991
Many people lose significant amounts of subcutaneous fat on GLP-1 medications while their visceral stores remain relatively intact
21 Mechanistically, the presence of GLP-1 receptors in the retina raises the possibility of a direct toxic effect of the GLP-1/GIP agonists leading to the observed retinopathy progression
These are estimates based on group means
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