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Frequent exposure of the esophagus to stomach acid can cause esophagitis, an inflammation of the esophagus that can lead to pain, ulcers, and difficulty swallowing
Signal 18 (1), 49 (2020)
So there have been those kinds of situations
Vegans, vegetarians, people over the age 50, anyone with stomach/bowel issues like chronic gastritis, leaky gut, IBS or celiac, and anyone who regularly takes medications such as Metformin, PPIs (used for GERD), H2 Receptor Antagonists (used for peptic ulcers), or anything that interferes with stomach acid production are actually at risk for vitamin B12 deficiency, and should supplement B12 regularly
PubMed: 11600700 Ipamorelin: A Selective Growth Hormone Secretagogue with Minimal Prolactin and Cortisol Effects human pilot Raun K, Hansen BS, Johansen NL, et al
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