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Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists, widely prescribed for type 2 diabetes and weight management, are known for their metabolic benefits but may have unrecognized side effects

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The further synergistic combination approach with other gastrointestinal hormones and creation of dual GIP/GLP-1 receptor agonists, such as tirzepatide and GLP-1/GIP/glucagon receptor triagonist, retatrutide, has shown unprecedented pharmacologically achieved weight loss with further cardiometabolic benefits in both obesity and T2DM

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In addition, bariatric surgery has been associated with long-term improvements in metabolic health leading to reductions in cardiovascular risk factors, cardiovascular events, microvascular complications of diabetes, cancer, and mortality (Cummings 2018)