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However, simply showing that the enzyme can cleave a substrate in vitro does not necessarily mean that DPP-4 plays an important physiological role in regulating concentrations and/or modulating biological activity of the endogenous molecules, particularly in humans and, for many of these putative substrates, there is little, if any experimental evidence to show that DPP-4 does actually cleave them in vivo and/or whether this has any physiological consequence

Whilst moderate alcohol consumption may be acceptable for some patients taking Wegovy, there are specific circumstances where complete abstinence is strongly advised

Reported hypotension was more common with retatrutide than with placebo, and fatigue and dizziness were reported more frequently in the higher-dose groups

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This mechanism improves glycaemic control and may contribute to weight loss in many patients with type 2 diabetes