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A pilot trial of melatonin in 22 breast cancer patients receiving paclitaxel- or docetaxel-based chemotherapy reported that 21 mg of daily melatonin appeared to reduce CIPN incidence (45%) and severity compared to historical controls (~60%) without impacting quality of life (Nahleh 2010)

L-carnitine can improve exercise tolerance in patients with diseases, such as indicators like exercise time, maximal oxygen uptake, and lactate threshold

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Kent Berridge, professor of psychology and neuroscience at the University of Michigan, has noted that GLP-1 drugs may lower the "wanting" component of pleasure -- the motivational drive toward rewarding experiences -- even if the capacity for "liking" remains intact